A Breakdown in Cooperativity Leads to Cardiac Identity Crisis
نویسندگان
چکیده
Using induced pluripotent stem cells, Ang et al. elucidate how a mutation in the transcription factor GATA4 causes congenital heart disease. They find that, although the recruitment of GATA4 to cardiac super-enhancers is retained, it no longer functions in partnership with another key transcription factor, leading to misexpression of non-cardiomyocyte genes.
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عنوان ژورنال:
- Cell
دوره 167 شماره
صفحات -
تاریخ انتشار 2016